(447) Valentine

Op-molb130231 434..447

The cation chloride cotransporter (CCCs) family comprises of four subfamilies—K + -Cl cotransporters (KCCs), Na + -K + -2Cl cotransporters (NKCCs), and Na + -Cl cotransporters (NCCs)—and possibly two additional members— CCC interacting protein (CIP1) and polyamine transporters (CCC9)—as well. Altogether, CCCs can play essential physiological roles in transepithelial ion reabsorption and secreti...

Dmd054932 441..447

Drug transporter inhibitors are important tools to elucidate the contribution of transporters to drug disposition both in vitro and in vivo. These inhibitors are often unselective and affect several transporters as well as drug metabolizing enzymes, which can make experimental results difficult to interpret with confidence. We therefore tested 14 commonly used P-glycoprotein (P-gp), breast canc...

Bez nazwy-447

Limnol. Oceanogr., 44(2), 1999, 447–454

Geophysical and ecological dynamics within lakes of the McMurdo Dry Valleys, Antarctica, are controlled by the presence of permanent ice covers. Despite the importance of the permanent ice cover, there have been no studies that have examined specific couplings between changes in the geophysical properties of the ice covers and dynamic ecological processes within the underlying water column. Her...

James W. Valentine

Jim Valentine went to college on the GI Bill (a WWII veterans privilege) and has been there ever since; at present he is Professor of Integrative Biology, Emeritus, at UC Berkeley. His early research was on what is now called macroecology, working with fossil marine faunas, leading to a book, Evolutionary Paleoecology of the Marine Biosphere. Those studies continue today, chiefly with colleague...